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Wilson and Hanks were admitted to Gold Coast University hospital in Queensland for treatment, where Wilson said she was given chloroquine after...
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Costedoat-Chalumeau N, Hulot JS, Amoura Z, Leroux G, Lechat P, Funck-Brentano C Heart conduction disorders related to antimalarials toxicity: An analysis of electrocardiograms in 85 patients treated with hydroxychloroquine for connective tissue diseases. Rheumatology. But doubts about the effectiveness of hydroxychloroquine had already begun to emerge among frontline clinicians, and were confirmed over time by larger studies that failed to show significant evidence of improvement among coronavirus patients. There is very low certainty in this comparison of treatment effect, mainly due to very high risk selection bias, making any claims of effectiveness highly uncertain. Furthermore, relying on intermediate outcomes, such as viral clearance to determine important outcomes for the patient (including a reduction in the development of pneumonia, hospital or ICU admission, or the need for intubation) adds another layer of imprecision.
Researchers at New York University Langone Health, a medical center, began adding zinc to their treatment plans for COVID-19 patients. In a study of 932 patient cases, the medical center found that the addition of zinc to hydroxychloroquine and azithromycin was associated with a decrease in mortality in patients who were not admitted to the intensive care unit. Further research should address the optimal dose and duration of treatment, and explore side effects and long-term outcomes.
Hydroxychloroquine retinopathy - implications of research advances for rheumatology care. This review analyzes existing approaches to the treatment of COVID-19 patients with antimalarial drugs from the standpoint of rational pharmacotherapy. The pharmaceutical giant behind the antiviral remdesivir, Gilead, released data on a study involving remdesivir and hydroxychloroquine.